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Title   원발성 악성 뇌종양에 대한 분자유전학적 연구 ( Molecular Genetic Study of Primary malignant Brain Tumors : Loss of Heterozygosity on Chromosome 10 , 13q , 17q and 22q )
Publicationinfo   1993 Jan; 025(05): 717-725.
Key_word   Malignant brain tumors, Glioma, Loss of heterozygosity(LOH)
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Abstract   Malignant brain tumors account for the vast majority of primary brain tumors and respond poorly to surgery, radiation and chematherapy. But the pathogenic mechanisms underlying tumor initiation, progression, malignancy and recurrence are not yet understood. We have employed a molecular genetic approach with polymorphic DNA marker for l0, l3q(RBl), 17p, 22q chromosome to detect loss of heterozygosity(LOH) in 23 cases of primary malignant brain tumors. LOH for loci on chromosome 10 were found only in four cases of malignant gliomas of 11 (36%) informative cases of malignant brain tumors. Allelic loss on RB I locus were seen in eight of 15(53%) informative cases. LOH on chromosome 17p was found in eleven of 21(52%) informative cases of malignant brain tumors, including 2 cases of anaplastic oligodendroglioma, 2 cases of malignant meningioma and 1 case of primitive neuroectodermal tumor(PNET). There was no allelic loss of chromosome 22q except one case of malignant meningioma. On the basis of the data presented here, LOH on chromosome 17p and 13q may be common genetic changes in malignant brain tumors. Allelic loss on chromosome 10q and 22q may be specific genetic events to malignant gliomas and meningioma respectively.
저 자   이승훈(Seung Hoon Lee),김종현(Jong Hyun Kim),이창훈(Chang Hoon Lee),강영순(Young Soon Kang),이제호(Je Ho Lee)